Iron-catalyzed olefin hydrogenation at 1 bar H2 with a FeCl3–LiAlH4catalyst

The scope and mechanism of a practical protocol for the iron-catalyzed hydrogenation of alkenes and alkynes at 1 bar H₂ pressure were studied. The catalyst is formed from cheap chemicals (5 mol% FeCl₃–LiAlH₄, THF). A homogeneous mechanism operates at early stages of the reaction while active nanoparticles form upon ageing of the catalyst solution.

Tim N. Gieshoff,^a   Matteo Villa,^a   Alice Welther,^a   Markus Plois,^b  Uttam Chakraborty,^b   Robert Wolf^b and  Axel Jacobi von Wangelin*^a  

*Corresponding authors

^aInstitute of Organic Chemistry, University of Regensburg, 93040 Regensburg, Germany

E-mail: axel.jacobi@ur.de

^bInstitute of Inorganic Chemistry, University of Regensburg, 93040 Regensburg, Germany

Green Chem., 2015, Advance Article

DOI: 10.1039/C4GC02368D

http://pubs.rsc.org/en/Content/ArticleLanding/2015/GC/C4GC02368D?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract

Prof. Dr. Axel Jacobi von Wangelin

1. FACULTY OF CHEMISTRY AND PHARMACY
2. Institute of Organic Chemistry

Research Group , Axel Jacobi von Wangelin

Building CH, 13.1.82

Phone +49 (0)941 943-4802
Fax +49 (0)941 943-4617

E-mail: axel.jacobi@ur.de

http://www.uni-regensburg.de/index.html.en

Professor of Organic Chemistry (2011), Heisenberg Group Leader (Cologne, 2011) Emmy Noether Group Leader (Cologne, 2005-2010), DAAD Postdoc (Stanford, B. M. Trost, 2003-2004), Postdoc (Cardiff, K. J. Cavell, 2003), Visiting Scientist (Degussa, 2002-2003), Ph.D. (Rostock, M. Beller, 2002), Visiting Scholar (Utah, J. A. Gladysz, 1999), M.Sc. (Erlangen, J. A. Gladysz, 1998), B.Sc. (Erlangen, 1994)

Awards: ORCHEM Award of the Liebig Association (2012), Heisenberg Fellow of the DFG (2011), Science Award of the Industrieclub (2009), Thieme Journal Award (2007), Emmy Noether Fellow of the DFG (2005-2010), DAAD Fellow (2003-2004), Joachim Jungius Dissertation Award (2002)

Most cited publications:

1. Coming of Age: Sustainable Iron-Catalyzed Cross-Coupling Reactions Times Cited: 285 (Web of Science Core Collection®)

2. Multicomponent coupling reactions for organic synthesis: Chemoselective reactions with amide-aldehyde mixtures Times Cited: 173 (Web of Science Core Collection®)

3. Dinuclear Zn-catalyzed asymmetric alkynylation of unsaturated aldehydes Times Cited: 155 (Web of Science Core Collection®)

http://www.researcherid.com/ProfileView.action?returnCode=ROUTER.Unauthorized&queryString=KG0UuZjN5WlnUgQXxhsj4VTS5Hx4sF8eU%252BJqDvjTrPk%253D&SrcApp=CR&Init=Yes

University of Regensburg

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  The campus in 2009

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  The old administration

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  University canteen

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  A student protest occupies a lecture theater, December 2009

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  Library Philosophicum 2

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  Library entrance hall

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  Athletics track and stand

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  Ball sculpture

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  Vielberth building, faculty of business

A Method to Identify Best Available Technologies (BAT) for Hydrogenation Reactors in the Pharmaceutical Industry

New Drug Approvals

J. Flow Chem. 2012, 2(3), 77–82

http://www.akademiai.com/content/8652651g3378x686/?p=ab7c1bc4cd7740e1855623297649f542&pi=3

http://www.akademiai.com/content/8652651g3378x686/fulltext.pdf

Journal of Flow Chemistry
Publisher	Akadémiai Kiadó
ISSN	2062-249X (Print) 2063-0212 (Online)
Subject	Flow Chemistry
Issue	Volume 2, Number 3/September 2012
Pages	77-82
DOI	10.1556/JFC-D-12-00014

Authors

Tuong Doan¹, Petr Stavárek¹, Claude Bellefon^{1 * Author for correspondence: claude.debellefon@lgpc.cpe.fr}

¹CNRS, CPE Lyon University of Lyon Villeurbanne France

Abstract

A methodology that may be applied to help in the choice of a continuous reactor is proposed. In this methodology, the chemistry is first described through the use of eight simple criteria (rate, thermicity, deactivation, solubility, conversion, selectivity, viscosity, and catalyst). Then, each reactor type is also analyzed from their capability to answer each of these criteria. A final score is presented using “spider diagrams.” Lower surfaces indicate the best reactor choice. The methodology is exemplified with a model substrate nitrobenzene and a target pharmaceutical intermediate, N-methyl-4-nitrobenzenemethanesulphonamide, and…

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