ELLAGIC ACID A CANCER FIGHTING WONDER

New Drug Approvals

Ellagic acid

ELLAGIC ACID

476-66-4 

2,3,7,8-Tetrahydroxy-chromeno[5,4,3-cde]chromene-5,10-dione

as a very potent CK2 inhibitor

Ellagic acid is a natural phenol antioxidant found in numerous fruits and vegetables. The antiproliferative and antioxidant properties of ellagic acid have spurred preliminary research into the potential health benefits of ellagic acid consumption.

Ellagic acid is the dilactone of hexahydroxydiphenic acid.

Ellagic acid is an antioxidant and an anti-proliferative compound present in fruits, nuts and vegetables. In spite of evidences for anticancer activity in various cancer cell-lines, human cancer cells, the mechanistic role of ellagic acid is not conclusive enough to be recommended for a clinical use. The present review provides information about the chemopreventive role of ellagic acid in oral cancer and proposes molecular basis for ellagic acid’s inhibitory activity against oral cancer. We show that ellagic acid modulates growth of tumor cells through regulation of multiple cell signaling pathways including cell proliferation…

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Chinese medicine…Cordyceps ( dong chong xia cao ) 冬蟲草 དབྱར་རྩྭ་དགུན་འབུ་ ………..to treat many diseases related to lungs, kidney, and also used as a natural Viagra.

New Drug Approvals

Ophiocordyceps sinensis (left) growing out of the head of a dead caterpillar

Ophiocordyceps sinensis is a fungus that parasitizes larvae of ghost moths and produces a fruiting body valued as an herbal remedy. The fungus germinates in the living larva, kills and mummifies it, and then the stalk-like fruiting body emerges from the corpse. It is known in English colloquially as caterpillar fungus, or by its more prominent foreign names (see below): yartsa gunbu or yatsa gunbu (Tibetan), or Dōng chóng xià cǎo (Chinese: 冬虫夏草; literally “winter worm, summer grass”). Of the various entomopathogenic fungi, Ophiocordyceps sinensis is one that has been used for at least 2000 years[2] to treat many diseases related to lungs, kidney, and also used as a natural Viagra. This fungus is not yet cultivated commercially,[3] despite the fact that several fermentable strains of Ophiocordyceps sinensis are isolated by Chinese Scientists.[4] Overharvesting and over exploitation have…

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BENZYL VINYL ETHER

ORGANIC CHEMISTRY SELECT

Green Chem., 2016, Advance Article

DOI: 10.1039/C5GC02977E, Communication

Ryosuke Matake, Yusuke Adachi, Hiroshi Matsubara

A convenient preparation of vinyl ethers from alcohols with calcium carbide was developed. This protocol is an alternative to the Favorskii-Reppe reaction without any high pressure device.

Vinyl ethers are important and useful synthetic building blocks. Using a test tube with a screw cap, a convenient preparation of vinyl ethers from alcohols with calcium carbide under superbasic catalytic conditions (KOH/DMSO) was developed. The vinylation of primary and secondary alcohols was successfully achieved, affording the desired products in good yields. The gram-scale preparation of a vinyl ether was also demonstrated. In this reaction, calcium carbide acts as an acetylene source, constituting a safer alternative to acetylene gas.

 F. de Nanteuil, E. Serrano, D. Perrotta and J. Waser, J. Am…

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