Carrots Cut Men’s Prostate Cancer Risk by 50%:

New Drug Approvals

Carrots Cut Men’s Prostate Cancer Risk by 50%: A new meta-study out of China has just shown that eating one large carrot (100 grams) daily may decrease prostate cancer risk by a stunning 50% in men. The study noted a 5% risk reduction for every 10 grams eaten daily, or full serving eaten weekly. But it’s not the beta-carotene that’s doing it. It’s the alpha-carotene (carrots are the richest source). This is confirmed by another very recent study out of Japan showing that men with the highest intake of alpha-carotene from all sources had 54% less risk of prostate cancer. And yet another study out of the USA showed men with the highest alpha-carotene intake were 51% less likely to have high PSA levels – a marker for prostate cancer. In both those studies, beta-carotene was found to offer no protection. Alpha-carotene is a powerful antioxidant: it’s also been shown to reduce the risk of breast cancer, bladder cancer, lung cancer, and pancreatic cancer in large population studies. Carrots are the single richest source of alpha-carotene in our diets, but pumpkin and winter squash (butternut, hubbard) are also good sources. It makes good sense, then, to get more of these low calorie super-vegetables (preferably organic) in our daily cuisine as part of a well-balanced, healthy diet including plentiful other organic vegetables, fruit and whole foods.<br /><br />
#ProstateCancer #Carrot #Carotene<br /><br />
http://www.ncbi.nlm.nih.gov/pubmed/24519559
Carrots Cut Men’s Prostate Cancer Risk by 50%
A new meta-study out of China has just shown that eating one large carrot (100 grams) daily may decrease prostate cancer risk by a stunning 50% in men. The study noted a 5% risk reduction for every 10 grams eaten daily, or full serving eaten weekly. But it’s not the beta-carotene that’s doing it. It’s the alpha-carotene (carrots are the richest source). This is confirmed by another very recent study out of Japan showing that men with the highest intake of alpha-carotene from all sources had 54% less risk of prostate cancer. And yet another study out of the USA showed men with the highest alpha-carotene intake were 51% less likely to have high PSA levels – a marker for prostate cancer. In both those studies, beta-carotene was found to offer no protection. Alpha-carotene is a powerful antioxidant: it’s also been shown…

View original post 77 more words

Advertisements

This Little Known Chinese Herb Kills 12,000 Cancer Cells For Every Healthy Cell

New Drug Approvals

WORMWOOD PLANT
This Little Known Chinese Herb Kills 12,000 Cancer Cells For Every Healthy Cell
collective-evolution.com
Today, odds are that you have had/have cancer, or know somebody who does. In Canada, approximately one million Canadians that were alive at…
read all at
or
A little known Chinese herb might be eligible for the growing list of cancer killers via alternative methods of treatment. According to  studies published  in Life Sciences, Cancer Letters and Anticancer Drugs, artemesinin, a derivative of the wormwood plant commonly used in Chinese medicine, can kill off  cancer cells, and do it at a rate of 12,000 cancer cells for every healthy cell.
Artemisinin is currently FDA approved for the treatment of malaria, it’s very safe and easy to use. It’s inexpensive and works on all cancers but has yet to find it’s way into the mainstream. It’s really time to move beyond just radiation, surgery and…

View original post 1,346 more words

Isoliquiritigenin Isolated from Liquorice Prevents Apoptosis in Neurons

Ayurvedic Herbal Teas

Liquorice is a popular medicinal herb containing antioxidative and anti-inflammatory bioactive components.

The effects of liquorice against Parkinson’s disease cell death were investigated with focus on Isoliquiritigenin (ISL) a key component of liquorice.

These results provide the first evidence that Isoliquiritigenin can protect dopaminergic cells under oxidative stress conditions by regulating the apoptotic process.

Dopaminergic cells are collections of neurons in the central nervous system that contain the neurotransmitter dopamine.

20120328-224243.jpg

Reference:
Hwang et al,
Bioscience, biotechnology, and biochemistry (Mar 27, 2012)

View original post

Green…Asymmetric hydrogentation of unfunctionalised olefins/enamines/imines

New Drug Approvals

Asymmetric hydrogentation of unfunctionalised olefins/enamines/imines

The reaction survey found that the predominant strategy for the introduction of chirality was through classical chemical resolutions as opposed to introductions through biotransformation or transition metal or organometallic catalytic means.

Asymmetric hydrogenation provides an elegant methodology for the introduction of chirality, meeting many of the goals of green chemistry and is finding increasing application in API synthesis.47

The efficiency of this approach is elegantly exemplified by the Merck second generation synthesis of sitagliptin 5 (Scheme ), where an unprecedented final stage asymmetric hydrogenation of the unprotected enamide 6 resulted in an increase in overall yield of almost 50% and produced 100 kg less waste per kg sitagliptin48 when compared with the first generation approach.49

The synthesis of sitigliptin.
Scheme  The synthesis of sitagliptin.

There are challenging areas remaining within the field, for example, the hydrogenation of enamides and related substrates in the synthesis of amino…

View original post 330 more words

GREEN CHEMISTRY…Reduction of amides without hydride reagents

New Drug Approvals

Clostridium sporogenes

Essentially all medicines and current drug candidates contain at least one basic nitrogen atom. A common approach to the synthesis of amines is to reduce the corresponding amide with a hydride reagent such as LiAlH4, DIBAL, RedAl, B2H6, Et3SiH, or polymethylhydroxysilane (PMHS).

The reaction survey reported that reduction of amides to amines was used in only 0.6% of chemical transformations; this number would surely be higher if safer methods for use on scale were available. The survey indicated that the number of amide reductions was equally split between diborane and hydride reagents.

Lithium aluminium hydride,

Wireframe model of lithium aluminium hydride

having a molecular weight of 38 and four hydrides per molecule, has the highest hydride density and is frequently used, even though it co-generates an inorganic by-product (lithium aluminum hydroxide) which is difficult to separate from the product. The workup procedure recommended by one bulk supplier…

View original post 457 more words

Neurotoxins in our environment threaten our brains, bodies and the planet

Everything Matters: Beyond Meds

We are actively poisoning ourselves and the environment. Insult after insult, from the time we’re in the womb. Those of us struck gravely ill from psychiatric drugs are part of this continuum of toxic exposures leading to all manner of illnesses and disability.

From The Atlantic:

Forty-one million IQ points. That’s what Dr. David Bellinger determined Americans have collectively forfeited as a result of exposure to lead, mercury, and organophosphate pesticides. In a 2012 paper published by the National Institutes of Health, Bellinger, a professor of neurology at Harvard Medical School, compared intelligence quotients among children whose mothers had been exposed to these neurotoxins while pregnant to those who had not. Bellinger calculates a total loss of 16.9 million IQ points due to exposure to organophosphates, the most common pesticides used in agriculture.

Last month, more research brought concerns about chemical exposure and brain health to a heightened pitch. Philippe…

View original post 350 more words

Sulfoaildenafil …. An analog of Sildenafil which has been used as an illegal adulterant in some dietary supplements

New Drug Approvals

Sulfoaildenafil.svg

Sulfoaildenafil

An analog of Sildenafil which has been used as an illegal adulterant in some dietary supplements.

856190-47-1  cas no

5-(5-(((3R,5S)-3,5-Dimethylpiperazin-1-yl)sulfonyl)-2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidine-7(4H)-thione

  • 7H-Pyrazolo(4,3-d)pyrimidine-7-thione, 5-(5-(((3R,5S)-3,5-dimethyl-1-piperazinyl)sulfonyl)-2-ethoxyphenyl)-1,6-dihydro-1-methyl-3-propyl-, rel-
  • Sildenafil thione
  • Thioaildenafil
  • UNII-33DX49E09G
    • C23-H32-N6-O3-S2
    • 504.6768

Sulfoaildenafil (thioaildenafil) is a synthetic chemical compound that is a structural analog of sildenafil (Viagra).[1] It was first reported in 2005,[2] and it is not approved by any health regulation agency. Like sildenafil, sulfoaildenafil is a phosphodiesterase type 5 inhibitor.

Sulfoaildenafil has been found as an adulterant in a variety of supplements which are sold as “natural” or “herbal” sexual enhancement products.[3][4][5][6] A range of designer analogues of USA FDA-approved inhibitors of type-5 cGMP-specific phosphodiesterase (PDE5), such as sildenafil and vardenafil, have been detected in recent years as adulturants in over-the-counter herbal aphrodisiac products and dietary supplements,[7][8][9] in…

View original post 1,095 more words