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Liquorice is a popular medicinal herb containing antioxidative and anti-inflammatory bioactive components.
The effects of liquorice against Parkinson’s disease cell death were investigated with focus on Isoliquiritigenin (ISL) a key component of liquorice.
These results provide the first evidence that Isoliquiritigenin can protect dopaminergic cells under oxidative stress conditions by regulating the apoptotic process.
Dopaminergic cells are collections of neurons in the central nervous system that contain the neurotransmitter dopamine.
Hwang et al,
Bioscience, biotechnology, and biochemistry (Mar 27, 2012)
Asymmetric hydrogentation of unfunctionalised olefins/enamines/imines
The reaction survey found that the predominant strategy for the introduction of chirality was through classical chemical resolutions as opposed to introductions through biotransformation or transition metal or organometallic catalytic means.
Asymmetric hydrogenation provides an elegant methodology for the introduction of chirality, meeting many of the goals of green chemistry and is finding increasing application in API synthesis.47
The efficiency of this approach is elegantly exemplified by the Merck second generation synthesis of sitagliptin 5 (Scheme ), where an unprecedented final stage asymmetric hydrogenation of the unprotected enamide 6 resulted in an increase in overall yield of almost 50% and produced 100 kg less waste per kg sitagliptin48 when compared with the first generation approach.49
|Scheme The synthesis of sitagliptin.|
There are challenging areas remaining within the field, for example, the hydrogenation of enamides and related substrates in the synthesis of amino…
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Essentially all medicines and current drug candidates contain at least one basic nitrogen atom. A common approach to the synthesis of amines is to reduce the corresponding amide with a hydride reagent such as LiAlH4, DIBAL, RedAl, B2H6, Et3SiH, or polymethylhydroxysilane (PMHS).
The reaction survey reported that reduction of amides to amines was used in only 0.6% of chemical transformations; this number would surely be higher if safer methods for use on scale were available. The survey indicated that the number of amide reductions was equally split between diborane and hydride reagents.
Lithium aluminium hydride,
having a molecular weight of 38 and four hydrides per molecule, has the highest hydride density and is frequently used, even though it co-generates an inorganic by-product (lithium aluminum hydroxide) which is difficult to separate from the product. The workup procedure recommended by one bulk supplier…
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We are actively poisoning ourselves and the environment. Insult after insult, from the time we’re in the womb. Those of us struck gravely ill from psychiatric drugs are part of this continuum of toxic exposures leading to all manner of illnesses and disability.
From The Atlantic:
Forty-one million IQ points. That’s what Dr. David Bellinger determined Americans have collectively forfeited as a result of exposure to lead, mercury, and organophosphate pesticides. In a 2012 paper published by the National Institutes of Health, Bellinger, a professor of neurology at Harvard Medical School, compared intelligence quotients among children whose mothers had been exposed to these neurotoxins while pregnant to those who had not. Bellinger calculates a total loss of 16.9 million IQ points due to exposure to organophosphates, the most common pesticides used in agriculture.
Last month, more research brought concerns about chemical exposure and brain health to a heightened pitch. Philippe…
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An analog of Sildenafil which has been used as an illegal adulterant in some dietary supplements.
856190-47-1 cas no
- 7H-Pyrazolo(4,3-d)pyrimidine-7-thione, 5-(5-(((3R,5S)-3,5-dimethyl-1-piperazinyl)sulfonyl)-2-ethoxyphenyl)-1,6-dihydro-1-methyl-3-propyl-, rel-
- Sildenafil thione
Sulfoaildenafil (thioaildenafil) is a synthetic chemical compound that is a structural analog of sildenafil (Viagra). It was first reported in 2005, and it is not approved by any health regulation agency. Like sildenafil, sulfoaildenafil is a phosphodiesterase type 5 inhibitor.
Sulfoaildenafil has been found as an adulterant in a variety of supplements which are sold as “natural” or “herbal” sexual enhancement products. A range of designer analogues of USA FDA-approved inhibitors of type-5 cGMP-specific phosphodiesterase (PDE5), such as sildenafil and vardenafil, have been detected in recent years as adulturants in over-the-counter herbal aphrodisiac products and dietary supplements, in…
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Effective Natural Remedies For Kidney Stones
Facts & Remedies You Should Know to Prevent and Cure Kidney Stones
If you have been diagnosed with kidney stones, you know how painful it is to live with these stones- big or small- in your kidneys. The acute pain in your left or right flanks going towards the lower abdomen and groin area and even towards your back is something that makes you shudder even if thought about. The feeling of nausea and vomiting along with the burning sensation while you pass urine and also the urgency and frequency of urinating, all these has led you to wish that you get rid of kidney stones as soon as possible.
While most kidney stones are small, it doesn’t mean they are harmless bunnies. One little stone in the urinary tract can make you suffer more than you can imagine.http://www.rapidhomeremedies.com/remedies-to-cure-kidney-stones.html
(NaturalNews) Researchers have just discovered that flavonoids extracted from common onions slow the rate of colon cancer growth in mice just as effectively as a chemotherapy drug. And while the mice on chemo saw their LDL cholesterol go up (a possible side effect of the drug), the mice on onion extract actually saw their LDL levels drop.
Onion flavonoids slow colon tumor growth by 67% in vivo
Fran (Dr. Kerton) will be giving a public lecture next week….the title is ‘Can Chemicals Be Green?’ It should come as no surprise that her answer will be ‘Yes’
Her talk will begin at 6.30 pm on Wednesday March 19th in the Fluvarium (a nature/interactive museum/aquarium) close to the University campus.
She will provide an overview of her studies in the field of Green Chemistry. She will also discuss the importance of mentors (from both sides of the partnership), teamwork, decision-making and risk-taking in scientific and technological careers.
You can register to attend by going to this website:
There will be a mixer and refreshments afterwards.