Lime juice as an efficient and green catalyst for the synthesis of 6-amino-4- aryl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile derivatives

ORGANIC CHEMISTRY SELECT

Vol 6, No 1, Feb.2014
……….

PDF

http://www.iranjoc.com/upfiles/Journals/vol6no1/j77a241.pdf

Iranian Journal of Organic Chemistry Vol. 6, No. 1 (2014) 1187-1192

Mehrnoosh kangania, Nourallah Hazeria*, Khatereh Khandan-Baranib, Mojtaba Lashkaric, and MalekTaher Maghsoodloua
aDepartment of Chemistry, University of Sistan and Baluchestan, P.O. Box 98135 – 674, Zahedan, Iran.
bDepartment of chemistry, Zahedan Branch, Islamic Azad University, Zahedan, Iran.
cFaculty of Sciences, Najafabad Branch, Islamic Azad University, Najafabad, Esfahan, Iran

www.iranjoc.com upfiles Journals vol6no1 j77a241.pdf

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Facile Synthesis of Bis(indolyl)methanes Catalyzed by α-Chymotrypsin

abstract graphic

Molecules 2014, 19(12), 19665-19677; doi:10.3390/molecules191219665

A mild and efficient method catalyzed by α-chymotrypsin was developed for the synthesis of bis(indolyl)methanes through a cascade process between indole and aromatic aldehydes. In the ethanol aqueous solution, a green medium, a wide range of aromatic aldehydes could react with indole to afford the desired products with moderate to good yields (from 68% to 95%) using a little α-chymotrypsin as catalyst.

Molecules 2014, 19(12), 19665-19677; doi:10.3390/molecules191219665

ORGANIC CHEMISTRY SELECT

“Facile multi-decagram synthesis of methyl but-2-ynoate” B. Darses, I. N. Michaelides, D. J. Dixon, Org. Chem. Front. 2014, 1, 117-119

Facile multi-decagram synthesis of methyl but-2-ynoate

 *Corresponding authors
aDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UK
Org. Chem. Front., 2014,1, 117-119

DOI: 10.1039/C3QO00072A

http://pubs.rsc.org/en/Content/ArticleLanding/2014/QO/c3qo00072a#!

A high yielding and operationally simple protocol affords multi-decagram quantities of the synthetically useful methyl but-2-ynoate from commercially available starting materials and reagents.

Graphical abstract: Facile multi-decagram synthesis of methyl but-2-ynoate
2d structure of methyl but-2-ynoateCAS 23326-27-4

MOLINSTINCTS ID:0001-5u7q

Formula:C5H6O2

IUPAC Name:methyl but-2-ynoate

Cite this record :MIID:0001-5u7q

methyl but-2-ynoate NMR spectra analysis, Chemical CAS NO. 23326-27-4 NMR spectral analysis, methyl but-2-ynoate C-NMR spectrum
methyl but-2-ynoate NMR spectra analysis, Chemical CAS NO. 23326-27-4 NMR spectral analysis, methyl but-2-ynoate H-NMR spectrum

Synthesis Route for 23326-27-4

67-56-1
Methanol
590-93-2
but-2-ynoic acid
~67%
23326-27-4
methyl but-2-yno…

Reference:

Viale, Alessandra; Santelia, Daniela; Napolitano, Roberta; Gobetto, Roberto; Dastru, Walter; Aime, Silvio European Journal of Inorganic Chemistry, 2008 , # 28 p. 4348 – 4351

Synthesis Route for

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MUSHROOM ALCOHOL

ORGANIC CHEMISTRY SELECT

1-Octen-3-ol, octenol for short and also known as mushroom alcohol,[1] is a chemical that attracts biting insects such asmosquitoes. It is contained in human breath and sweat, and it was once believed that insect repellentDEET works by blocking the insects’ octenol odorantreceptors.[2][3] 1-Octen-3-ol is a secondary alcohol derived from 1-octene. It exists in the form of twoenantiomers, (R)-(–)-1-octen-3-ol and (S)-(+)-1-octen-3-ol.

NMR……..https://www.jstage.jst.go.jp/article/cl1972/6/8/6_8_975/_pdf

IR(film):3350(OH)and 920cm-1(CH2=);NMR(CCl4)δ 0.90(t,3H,CH3CH2-),1.36
(m,8H,-(CH2)4-),1.96(s,1H,-OH),4.07(m,1H, CHOH),4.90-5.40(m,2H, CH2=),
and 5.55-6.20 (m, 1H, -CH=).

Natural occurrence

Octenol is produced by several plants and fungi, including edible mushrooms and Lemon balm. Octenol is formed during oxidative breakdown of linoleic acid.[4]

It is also a wine fault, defined as a cork taint, occurring in wines made with bunch rot contaminated grape.[5]

Uses

Octenol is used, sometimes in combination with carbon…

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A truly green synthesis of α-aminonitriles via Strecker reaction

A truly green synthesis of α-aminonitriles via Strecker reaction

Debasish Bandyopadhyay, Juliana M Velazquez, Bimal K BanikOrganic and Medicinal Chemistry Letters 2011, 1:11 (4 October 2011)

Background

The classical Strecker reaction is one of the simplest and most economical methods for the synthesis of racemic α-aminonitriles (precursor of α-amino acids) and pharmacologically useful compounds.

Results

Indium powder in water is shown to act as a very efficient catalyst for one-pot, three-component synthesis of α-aminonitriles from diverse amines, aldehydes and TMSCN. This general rapid method is applicable to a wide range of amines and aldehydes and produces products in excellent yield.

Conclusions

The present one-pot, three-component environmentally benign procedure for the synthesis of α-aminonitriles will find application in the synthesis of complex biologically active molecules.

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