Alternative solvents can make preparative liquid chromatography greener

New Drug Approvals

Green Chem., 2015, Advance Article
DOI: 10.1039/C5GC00887E, Paper
Yao Shen, Bo Chen, Teris A. van Beek

Alternative solvents can make preparative liquid chromatography greener

Yao Shen,*ab  Bo Chenb and  Teris A. van Beeka  
*Corresponding authors
aLaboratory of Organic Chemistry, Wageningen University, Dreijenplein 8, 6703 HB Wageningen, The Netherlands
bKey Laboratory of Phytochemical R&D of Hunan Province, Hunan Normal University, Changsha, PR China
Greener ethanol, acetone and ethyl acetate provided better chromatographic resolution in preparative RP-HPLC than the traditional methanol, acetonitrile and tetrahydrofuran.

Alternative solvents can make preparative liquid chromatography greener

To make preparative Reversed-Phase High Performance Liquid Chromatography (RP-pHPLC) greener, alternative solvents were considered among others in terms of toxicity, cost, safety, workability, chromatographic selectivity and elution strength. The less toxic solvents ethanol, acetone and ethyl acetate were proposed as possible greener replacements for methanol, acetonitrile…

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Food as medicine. Food sensitivities, too.

Everything Matters

FoodFood and diet has been critically important to my healing journey. I intend to write more about food sensitivities as I move forward.  I’m working on developing language around how they work as a liaison to the psyche. They are profound teachers that humble me again and again and teach me all manner of things about the nature of being human. I am finding more and more people who understand them in this way. What we are finding is that there is some spiritual significance in the very real (and sometimes potentially deadly) physical, biological and physiological reactions that so many people on the planet are experiencing with foods that used to be safe to eat. Of course there is also environmental significance to the phenomena. There is a lot of evidence that the very poor care of the food supply has made these issues worse for many people. This is why…

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Suzuki cross-coupling in aqueous media

*Corresponding authors
aFriedrich-Alexander University Erlangen-Nürnberg, Department of Organic Chemistry I, Henkestraße 42, 91054 Erlangen, Germany
Fax: +49 9131 85 24707
Tel: +49 9131 85 25766
Green Chem., 2015, Advance Article

DOI: 10.1039/C5GC00794A

Ina Hoffmann, Bettina Blumenroder, Silvia Onodi nee Thumann, Sabine Dommer, Jurgen Schatz
Efficient and generally applicable ligand-less and ligand-supported Suzuki coupling reactions in pure water under aerobic conditions.
We report a simple and efficient procedure for the ligand-free as well as ligand-assisted Suzuki reaction in both pure water and aqueous media. The cross-coupling reactions proceed successfully using phenylboronic acid or potassium phenyltrifluoroborate as a nucleophilic coupling partner. The method can be effectively applied to both activated and deactivated aryl halides yielding quantitative conversions. The catalytic activity of couplings performed in pure water increases when utilizing supramolecular additives, but decreases under standard phase-transfer conditions. Finally, the palladium loading is reducible from 3.0 mol% to 0.4 mol% without any loss of conversion.
 Erlangen, Germany
MOBILE-+91 9323115463
web link

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