Alternative solvents can make preparative liquid chromatography greener

New Drug Approvals

Green Chem., 2015, Advance Article
DOI: 10.1039/C5GC00887E, Paper
Yao Shen, Bo Chen, Teris A. van Beek

Alternative solvents can make preparative liquid chromatography greener

Yao Shen,*ab  Bo Chenb and  Teris A. van Beeka  
*Corresponding authors
aLaboratory of Organic Chemistry, Wageningen University, Dreijenplein 8, 6703 HB Wageningen, The Netherlands
E-mail: lvy33@163.com
bKey Laboratory of Phytochemical R&D of Hunan Province, Hunan Normal University, Changsha, PR China
Greener ethanol, acetone and ethyl acetate provided better chromatographic resolution in preparative RP-HPLC than the traditional methanol, acetonitrile and tetrahydrofuran.

Alternative solvents can make preparative liquid chromatography greener

To make preparative Reversed-Phase High Performance Liquid Chromatography (RP-pHPLC) greener, alternative solvents were considered among others in terms of toxicity, cost, safety, workability, chromatographic selectivity and elution strength. The less toxic solvents ethanol, acetone and ethyl acetate were proposed as possible greener replacements for methanol, acetonitrile…

View original post 190 more words

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s