Eco-friendly synthesis of pyridines via rhodium-catalyzed cyclization of diynes with oximes

Eco-friendly synthesis of pyridines via rhodium-catalyzed cyclization of diynes with oximes

Green Chem., 2015, Advance Article
DOI: 10.1039/C4GC01756K, Communication
Fen Xu, Chunxiang Wang, Haolong Wang, Xincheng Li, Boshun Wan
We describe a new route for the synthesis of pyridines via [2 + 2 + 2] cycloaddition of diynes and oximes catalyzed by Rh(NBD)2BF4/MeO-Biphep using ethanol as an alternative reaction medium, affording the desired pyridine derivatives in yields of up to 93%.
We describe a new route for the synthesis of pyridines via [2 + 2 + 2] cycloaddition of diynes and oximes catalyzed by Rh(NBD)2BF4/MeO-Biphep using ethanol as an alternative green reaction medium, affording the desired pyridine derivatives in yields of up to 93%. This environmentally friendly method meets the requirement for green chemistry by minimizing pollution from solvents and is tolerant of a range of functional groups.
Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s