Common Chemical found in unripe fruits and yoghurt could serve as a protection against Parkinson’s

ClinicalNews.Org

Potential basis for the treatment and prevention of Parkinson’s disease

Max Planck researchers show that two products of the gene DJ-1 can increase the survival of neurons

July 31, 2014

Parkinson’s disease affects neurons in the Substantia nigra brain region – their mitochondrial activity ceases and the cells die. Researchers at the Max Planck Institute of Molecular Cell Biology and Genetics show that supplying D-lactate or glycolate, two products of the gene DJ-1, can stop and even counteract this process: Adding the substances to cultured HeLa cells and to cells of the nematode C. elegans restored the activity of mitochondria and prevented the degeneration of neurons. They also showed that the two substances rescued the toxic effects of the weed killer Paraquat. Cells that had been treated with this herbicide, which is known to cause a Parkinson’s like harm of mitochondria, recovered after the addition of the two substances. Both…

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