Multihormone reverses metabolic damage of high calorie diet

Lyra Nara Blog

Importantly, the scientists found out that treatment of obese mice with this GLP-1/Glucagon co-agonist improves metabolism and body weight associated with restored function of the weight lowering hormone leptin, even in the continued presence of a high-fat, high-sugar diet. The results are published in the current issue of the official journal of the American Diabetes Association Diabetes.

The adipocyte hormone leptin plays a key role in the physiology of energy and glucose metabolism. Leptin is normally secreted from adipose tissue to blood in proportion to the amount of body fat. Increased leptin levels inform the brain of stored calories and it responds to inhibit food intake, increase energy expenditure and decrease blood glucose. However, obese individuals are resistant to leptin’s metabolic effects, which limits the use of leptin as an anti-obesity drug. In their new study, the group of Dr. Timo Müller (Institute of Diabetes and Obesity, Helmholtz…

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