Is zinc the missing link for osteoarthritis therapies?

Lyra Nara Blog

Osteoarthritis is a leading cause of disability, characterized by the destruction of cartilage tissue in joints, but there is a lack of effective therapies because the underlying molecular causes have been unclear. A study published by Cell Press February 13th in the journal Cell reveals that osteoarthritis-related tissue damage is caused by a molecular pathway that is involved in regulating and responding to zinc levels inside of cartilage cells. A protein called ZIP8 transports zinc inside these cells, setting off a cascade of molecular events that result in the destruction of cartilage tissue in mice. The findings could lead to a new generation of therapies for osteoarthritis.

“No evidence available to date clearly indicated that zinc plays a causal role in osteoarthritis,” says senior study author Jang-Soo Chun of the Gwangju Institute of Science and Technology. “In our study, we revealed the entire series of molecular events in the osteoarthritis…

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