Lime juice as an efficient and green catalyst for the synthesis of 6-amino-4- aryl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile derivatives

ORGANIC CHEMISTRY SELECT

Vol 6, No 1, Feb.2014
……….

PDF

http://www.iranjoc.com/upfiles/Journals/vol6no1/j77a241.pdf

Iranian Journal of Organic Chemistry Vol. 6, No. 1 (2014) 1187-1192

Mehrnoosh kangania, Nourallah Hazeria*, Khatereh Khandan-Baranib, Mojtaba Lashkaric, and MalekTaher Maghsoodloua
aDepartment of Chemistry, University of Sistan and Baluchestan, P.O. Box 98135 – 674, Zahedan, Iran.
bDepartment of chemistry, Zahedan Branch, Islamic Azad University, Zahedan, Iran.
cFaculty of Sciences, Najafabad Branch, Islamic Azad University, Najafabad, Esfahan, Iran

www.iranjoc.com upfiles Journals vol6no1 j77a241.pdf

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Facile Synthesis of Bis(indolyl)methanes Catalyzed by α-Chymotrypsin

abstract graphic

Molecules 2014, 19(12), 19665-19677; doi:10.3390/molecules191219665

A mild and efficient method catalyzed by α-chymotrypsin was developed for the synthesis of bis(indolyl)methanes through a cascade process between indole and aromatic aldehydes. In the ethanol aqueous solution, a green medium, a wide range of aromatic aldehydes could react with indole to afford the desired products with moderate to good yields (from 68% to 95%) using a little α-chymotrypsin as catalyst.

Molecules 2014, 19(12), 19665-19677; doi:10.3390/molecules191219665

ORGANIC CHEMISTRY SELECT

“Facile multi-decagram synthesis of methyl but-2-ynoate” B. Darses, I. N. Michaelides, D. J. Dixon, Org. Chem. Front. 2014, 1, 117-119

Facile multi-decagram synthesis of methyl but-2-ynoate

 *Corresponding authors
aDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UK
Org. Chem. Front., 2014,1, 117-119

DOI: 10.1039/C3QO00072A

http://pubs.rsc.org/en/Content/ArticleLanding/2014/QO/c3qo00072a#!

A high yielding and operationally simple protocol affords multi-decagram quantities of the synthetically useful methyl but-2-ynoate from commercially available starting materials and reagents.

Graphical abstract: Facile multi-decagram synthesis of methyl but-2-ynoate

MOLINSTINCTS ID:0001-5u7q

Formula:C5H6O2

IUPAC Name:methyl but-2-ynoate

Cite this record :MIID:0001-5u7q

methyl but-2-ynoate NMR spectra analysis, Chemical CAS NO. 23326-27-4 NMR spectral analysis, methyl but-2-ynoate C-NMR spectrum
methyl but-2-ynoate NMR spectra analysis, Chemical CAS NO. 23326-27-4 NMR spectral analysis, methyl but-2-ynoate H-NMR spectrum

Synthesis Route for 23326-27-4

67-56-1
Methanol
590-93-2
but-2-ynoic acid
~67%
23326-27-4
methyl but-2-yno…

Reference:

Viale, Alessandra; Santelia, Daniela; Napolitano, Roberta; Gobetto, Roberto; Dastru, Walter; Aime, Silvio European Journal of Inorganic Chemistry, 2008 , # 28 p. 4348 – 4351

Synthesis Route for

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MUSHROOM ALCOHOL

ORGANIC CHEMISTRY SELECT

1-Octen-3-ol, octenol for short and also known as mushroom alcohol,[1] is a chemical that attracts biting insects such asmosquitoes. It is contained in human breath and sweat, and it was once believed that insect repellentDEET works by blocking the insects’ octenol odorantreceptors.[2][3] 1-Octen-3-ol is a secondary alcohol derived from 1-octene. It exists in the form of twoenantiomers, (R)-(–)-1-octen-3-ol and (S)-(+)-1-octen-3-ol.

NMR……..https://www.jstage.jst.go.jp/article/cl1972/6/8/6_8_975/_pdf

IR(film):3350(OH)and 920cm-1(CH2=);NMR(CCl4)δ 0.90(t,3H,CH3CH2-),1.36
(m,8H,-(CH2)4-),1.96(s,1H,-OH),4.07(m,1H, CHOH),4.90-5.40(m,2H, CH2=),
and 5.55-6.20 (m, 1H, -CH=).

Natural occurrence

Octenol is produced by several plants and fungi, including edible mushrooms and Lemon balm. Octenol is formed during oxidative breakdown of linoleic acid.[4]

It is also a wine fault, defined as a cork taint, occurring in wines made with bunch rot contaminated grape.[5]

Uses

Octenol is used, sometimes in combination with carbon…

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A truly green synthesis of α-aminonitriles via Strecker reaction

A truly green synthesis of α-aminonitriles via Strecker reaction

Debasish Bandyopadhyay, Juliana M Velazquez, Bimal K BanikOrganic and Medicinal Chemistry Letters 2011, 1:11 (4 October 2011)

Background

The classical Strecker reaction is one of the simplest and most economical methods for the synthesis of racemic α-aminonitriles (precursor of α-amino acids) and pharmacologically useful compounds.

Results

Indium powder in water is shown to act as a very efficient catalyst for one-pot, three-component synthesis of α-aminonitriles from diverse amines, aldehydes and TMSCN. This general rapid method is applicable to a wide range of amines and aldehydes and produces products in excellent yield.

Conclusions

The present one-pot, three-component environmentally benign procedure for the synthesis of α-aminonitriles will find application in the synthesis of complex biologically active molecules.

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The Paal-Knorr reaction revisited. A catalyst and solvent-free synthesis of underivatized and N-substituted pyrroles

The Paal-Knorr reaction revisited. A catalyst and solvent-free synthesis of underivatized and N-substituted pyrroles

Green Chem., 2015, Advance Article
DOI: 10.1039/C4GC01523A, Paper
Hyejin Cho, Richard Madden, Bilal Nisanci, Bela Torok
A catalyst and solvent-free room temperature synthesis of pyrroles is described.
A new, modified synthesis of pyrroles is described. The reaction of 2,5-hexandione with a variety of amines yielded the expected pyrrole analogues in excellent yields. The reactions were carried out under the ultimate green conditions excluding both catalyst and solvent applying simple stirring at room temperature. The variety of amines include aqueous ammonium hydroxide for the synthesis of pyrroles with a free NH group, and benzylamines, anilines and phenylene-diamines for the synthesis of several N-derivatized pyrroles. The reaction also occurs efficiently with a variety of 1,4-diketones, although the reaction rates and yields are lower for the diketones that do not possess terminal methyl group(s).

Eco-friendly synthesis of pyridines via rhodium-catalyzed cyclization of diynes with oximes

Eco-friendly synthesis of pyridines via rhodium-catalyzed cyclization of diynes with oximes

Green Chem., 2015, Advance Article
DOI: 10.1039/C4GC01756K, Communication
Fen Xu, Chunxiang Wang, Haolong Wang, Xincheng Li, Boshun Wan
We describe a new route for the synthesis of pyridines via [2 + 2 + 2] cycloaddition of diynes and oximes catalyzed by Rh(NBD)2BF4/MeO-Biphep using ethanol as an alternative reaction medium, affording the desired pyridine derivatives in yields of up to 93%.
We describe a new route for the synthesis of pyridines via [2 + 2 + 2] cycloaddition of diynes and oximes catalyzed by Rh(NBD)2BF4/MeO-Biphep using ethanol as an alternative green reaction medium, affording the desired pyridine derivatives in yields of up to 93%. This environmentally friendly method meets the requirement for green chemistry by minimizing pollution from solvents and is tolerant of a range of functional groups.