Cross-Coupling Triple Play Green Chemistry: Popular reactions using specialized boron reagents can now be run in water

THREE-IN-ONE STRATEGY
In aqueous micelle solutions made using the surfactant TPGS-750-M, even unstable 2-pyridyl boronates readily undergo Suzuki-Miyaura cross-coupling.
Chemists have taken one of the most widely used reactions in organic synthesis—the Suzuki-Miyaura cross-coupling reaction—and made it even more versatile by melding it with an award-winning green chemistry technology. The new development will help researchers, particularly those working in drug discovery, expand the range of compounds that can be made using the cross-coupling approach and create safer and environmentally friendly processes that avoid organic solvents, excess reagents, and high temperatures.
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