A convenient guide to help select replacement solvents for dichloromethane in chromatography

Graphical abstract: A convenient guide to help select replacement solvents for dichloromethane in chromatography

http://pubs.rsc.org/en/content/articlelanding/2012/gc/c2gc36064k

Green Chemistry

Issue 11, 2012

The home of cutting-edge research on the development of alternative sustainable technologies.

Joshua P. Taygerly ET AL

Green Chem., 2012,14, 3020-3025
DOI: 10.1039/C2GC36064K

One of the largest contributors to chlorinated solvent waste in medicinal chemistry is chromatography. A set of “drug-like” compounds was employed to compare the relative eluting strengths of greener solvent systems. Disclosed herein is an experimentally-derived solvent selection guide to aid chemists in choosing greener solvents for chromatographic purification, with a particular focus on reducing dichloromethane usage.

 

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