One-pot synthesis of 2H-phenanthro[9,10-c]pyrazoles from isoflavones by two dehydration processes

One-pot synthesis of 2H-phenanthro[9,10-c]pyrazoles from isoflavones by two dehydration processes

Green Chem., 2013, 15,1048-1054
DOI: 10.1039/C3GC40205C, Paper
Qiuya Wang, Zunting Zhang, Zichao Du, Huiliang Hua, Shasha Chen
china
An environmentally friendly and efficient procedure has been developed for one-pot synthesis of 2H-phenanthro[9,10-c]pyrazoles from isoflavones by two dehydration processes in EtOH.
An environmentally friendly and efficient method was developed for one-pot synthesis of a series of 2H-phenanthro[9,10-c]pyrazoles in EtOH by two dehydration processes.
Firstly, 3,4-diaryl-1H-pyrazoles were synthesized by the cyclocondensation of isoflavones and hydrazine hydrate in refluxing EtOH.
Secondly, the final target products 2H-phenanthro[9,10-c]pyrazoles were given by photocyclization and dehydration of 3,4-diaryl-1H-pyrazoles in 1 : 1 (v/v) EtOH–H2O.
The advantages of this method are catalyst-free, short synthetic routes, mild reaction conditions and easy work-up. In addition, the fluorescence properties of 2H-phenanthro[9,10-c]pyrazoles were determined.
Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s